Clinical Research

PDF comparison for clinical research

Protocol amendment 3 changes the dosing schedule and two inclusion criteria. Compare it against amendment 2 and get a change list a monitor or an ethics committee can review in minutes.

What clinical research teams compare

Trial protocols, amendments, investigator brochures, informed consent forms.

What you get

How the comparison works

Text is extracted from both PDFs with its position and style. Repeating headers, footers and page numbers are removed, unchanged tables are recognised and held out, and paragraphs are aligned across the two documents before a character-level comparison. The output is a change list with page numbers, a redlined PDF and a side-by-side view with synced scrolling. The engine is deterministic: the same two documents always produce the same result.

Deployment options

Use the web tool for individual reviews, the REST API to trigger comparisons from your document system, or a private deployment in your own VPC or on-premises when documents cannot leave your network.

Questions from clinical research teams

Is the result reproducible?

Yes. The comparison is deterministic. The same two PDFs always produce the same change list.

Can it compare documents with different page counts?

Yes. Content is aligned by paragraph, not by page, so an inserted section does not push every later page out of alignment.

Further reading

Related industries

Run it on your own documents

Bring two real revisions to a 20-minute call and watch the comparison run.

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